The Neo-Byzantine church was built in 1910 based on the plans of János Bobula. Unlike other Greek Orthodox churches, there is no iconostasis here.
The inlaid altar and pulpit with mosaic ornaments were also prepared in 1910. Valuable seccos and colorful glass windows decorate the church.
Debrecen’s Greek Orthodox community belonged to the Greek Orthodox Archdiocesan District of Hajdúdorog until 1899. The first Greek Orthodox chapel opened in December 1900, in a rented building, but by the summer of 1910, an independent church was built from the community’s donations. The Greek Orthodox Metropolis with Debrecen as its center was founded by Pope Francis during the month of April 2017.